Cloche is a bHLH-PAS transcription factor that drives haemato-vascular specification.

doi:10.1038/nature18614

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Cloche is a bHLH-PAS transcription factor that drives haemato-vascular specification.

Nature - 14 Jul 2016

Reischauer Sven, Stone Oliver A, Villasenor Alethia, Chi Neil, Jin Suk-Won, Martin Marcel, Lee Miler T, Fukuda Nana, Marass Michele, Witty Alec, Fiddes Ian, Kuo Taiyi, Chung Won-Suk, Salek Sherveen, Lerrigo Robert, Alsiö Jessica, Luo Shujun, Tworus Dominika, Augustine Sruthy M, Mucenieks Sophie, Nystedt Björn, Giraldez Antonio J, Schroth Gary P, Andersson Olov, Stainier Didier Y R

Abstract excerpt

Vascular and haematopoietic cells organize into specialized tissues during early embryogenesis to supply essential nutrients to all organs and thus play critical roles in development and disease. At the top of the haemato-vascular specification cascade lies cloche, a gene that when mutated in zebrafish leads to the striking phenotype of loss of most endothelial and haematopoietic cells and a significant increase...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Basic Helix-Loop-Helix Transcription Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Blood Cells

Share to Blood Vessels

Share to Endothelial Cells

Share to Helix-Loop-Helix Motifs

Share to Hematopoiesis

Share to Mesoderm

Share to T-Cell Acute Lymphocytic Leukemia Protein 1

Source

Open in PubMed

Identifiers

PMID: 27411634
DOI: 10.1038/nature18614

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cloche is a bHLH-PAS transcription factor that drives haemato-vascular specification.PMID 27411634Read ↗

Identification of novel vascular endothelial-specific genes by the microarray analysis of the zebrafish cloche mutants.Semantic proximity Read ↗

Mutant-specific gene expression profiling identifies SRY-related HMG box 11b (SOX11b) as a novel regulator of vascular development in zebrafish.Semantic proximity Read ↗

Cloche, an early acting zebrafish gene, is required by both the endothelial and hematopoietic lineages.Semantic proximity Read ↗

Zebrafish Kelch-like family member 4 is required for vasculogenesis and hematopoiesis.Semantic proximity Read ↗

Development: For cloche the Bell Tolls.Semantic proximity Read ↗

Mutant-specific gene programs in the zebrafish.Semantic proximity Read ↗

Loss of Apela Peptide in Mice Causes Low Penetrance Embryonic Lethality and Defects in Early Mesodermal Derivatives.Semantic proximity Read ↗

Characterization of a weak allele of zebrafish cloche mutant.Semantic proximity Read ↗

Endothelial‐to‐mesenchymal transition in cardiovascular diseases: Developmental signaling pathways gone awrySemantic proximity Read ↗

Common genetic control of haemangioblast and cardiac development in zebrafishSemantic proximity Read ↗

The cloche and spadetail genes differentially affect hematopoiesis and vasculogenesis.Semantic proximity Read ↗

An acyltransferase controls the generation of hematopoietic and endothelial lineages in zebrafish.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.