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Article

The paralogous hematopoietic regulators Lyl1 and Scl are coregulated by Ets and GATA factors, but Lyl1 cannot rescue the early Scl-/- phenotype.

Blood - 1 Mar 2007

Chan Wan Y I, Follows George A, Lacaud Georges, Pimanda John E, Landry Josette-Renee, Kinston Sarah, Knezevic Kathy, Piltz Sandie, Donaldson Ian J, Gambardella Laure, Sablitzky Fred, Green Anthony R, Kouskoff Valerie, Göttgens Berthold

Abstract excerpt

Transcription factors are key regulators of hematopoietic stem cells (HSCs), yet the molecular mechanisms that control their expression are largely unknown. Previously, we demonstrated that expression of Scl/Tal1, a transcription factor required for the specification of HSCs, is controlled by Ets and GATA factors. Here we characterize the molecular mechanisms controlling expression of Lyl1, a paralog of Scl also...

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PMID: 17053063
DOI: 10.1182/blood-2006-05-023226

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The paralogous hematopoietic regulators Lyl1 and Scl are coregulated by Ets and GATA factors, but Lyl1 cannot rescue the early Scl-/- phenotype.PMID 17053063Read ↗

Adult hematopoietic stem and progenitor cells require either Lyl1 or Scl for survival.Semantic proximity Read ↗

Shared roles for Scl and Lyl1 in murine platelet production and functionSemantic proximity Read ↗

Transcriptional Regulation of the SCL Locus: Identification of an Enhancer That Targets the Primitive Erythroid Lineage In VivoSemantic proximity Read ↗

Rescue of the lethal scl(-/-) phenotype by the human SCL locus.Semantic proximity Read ↗

Differential use of SCL/TAL-1 DNA-binding domain in developmental hematopoiesisSemantic proximity Read ↗

SCL/tal-1-dependent process determines a competence to select the definitive hematopoietic lineage prior to endothelial differentiation.Semantic proximity Read ↗

The scl gene product is required for the generation of all hematopoietic lineages in the adult mouse.Semantic proximity Read ↗

Absence of yolk sac hematopoiesis from mice with a targeted disruption of the scl gene.Semantic proximity Read ↗

SCL/Tal-1 transcription factor acts downstream of cloche to specify hematopoietic and vascular progenitors in zebrafish.Semantic proximity Read ↗

Distinct Functions for Different scl Isoforms in Zebrafish Primitive and Definitive HematopoiesisSemantic proximity Read ↗

Tetracycline-controlled transgenic targeting from the SCL locus directs conditional expression to erythrocytes, megakaryocytes, granulocytes, and c-kit-expressing lineage-negative hematopoietic cells.Semantic proximity Read ↗

The T cell leukemia oncoprotein SCL/tal-1 is essential for development of all hematopoietic lineages.Semantic proximity Read ↗

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