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Article

Rescue of the lethal scl(-/-) phenotype by the human SCL locus.

Blood - 1 Jun 2002

Sinclair Angus M, Bench Anthony J, Bloor Adrian J C, Li Juan, Göttgens Berthold, Stanley Maureen L, Miller Jane, Piltz Sandie, Hunter Susie, Nacheva Elisabeth P, Sanchez María-José, Green Anthony R

Abstract excerpt

The stem cell leukemia (SCL) gene encodes a basic helix-loop-helix transcription factor with a critical role in the development of both blood and endothelium. Loss-of-function studies have shown that SCL is essential for the formation of hematopoietic stem cells, for subsequent erythroid development and for yolk sac angiogenesis. SCL exhibits a highly conserved pattern of expression from mammals to teleost fish....

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Identifiers

PMID: 12010791
DOI: 10.1182/blood.v99.11.3931

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rescue of the lethal scl(-/-) phenotype by the human SCL locus.PMID 12010791Read ↗

Absence of yolk sac hematopoiesis from mice with a targeted disruption of the scl gene.Semantic proximity Read ↗

The paralogous hematopoietic regulators Lyl1 and Scl are coregulated by Ets and GATA factors, but Lyl1 cannot rescue the early Scl-/- phenotype.Semantic proximity Read ↗

Adult hematopoietic stem and progenitor cells require either Lyl1 or Scl for survival.Semantic proximity Read ↗

Transcriptional Regulation of the SCL Locus: Identification of an Enhancer That Targets the Primitive Erythroid Lineage In VivoSemantic proximity Read ↗

Specification of hematopoietic and vascular development by the bHLH transcription factor SCL without direct DNA binding.Semantic proximity Read ↗

The SCL Gene Is Formed from a Transcriptionally Complex LocusSemantic proximity Read ↗

Long-range comparison of human and mouse SCL loci: localized regions of sensitivity to restriction endonucleases correspond precisely with peaks of conserved noncoding sequences.Semantic proximity Read ↗

The scl gene product is required for the generation of all hematopoietic lineages in the adult mouse.Semantic proximity Read ↗

Tetracycline-controlled transgenic targeting from the SCL locus directs conditional expression to erythrocytes, megakaryocytes, granulocytes, and c-kit-expressing lineage-negative hematopoietic cells.Semantic proximity Read ↗

Distinct roles for SCL in erythroid specification and maturation in zebrafish.Semantic proximity Read ↗

Differential use of SCL/TAL-1 DNA-binding domain in developmental hematopoiesisSemantic proximity Read ↗

Distinct Functions for Different scl Isoforms in Zebrafish Primitive and Definitive HematopoiesisSemantic proximity Read ↗

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