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Article

Genetic Dissection of Tie Pathway in Mouse Lymphatic Maturation and Valve Development

25 Apr 2014

Abstract excerpt

OBJECTIVE: The genetic program underlying lymphatic development is still incompletely understood. This study aims to dissect the role of receptor tyrosine kinase with immunoglobulin-like and EGF (epidermal growth factor)-like domains 1 (Tie1) and Tie2 in lymphatic formation using genetically modified mouse models. APPROACH AND RESULTS: We generated conditional knockout mouse models targeting Tie1, Tie2, and...

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PMID: 24764452
DOI: 10.1161/atvbaha.113.302923

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