Article
The receptor tyrosine kinase TIE is required for integrity and survival of vascular endothelial cells.
The EMBO journal - 1 Dec 1995
Puri M C, Rossant J, Alitalo K, Bernstein A, Partanen J
Abstract excerpt
Vascular endothelial cells are critical for the development and function of the mammalian circulatory system. We have analyzed the role of the endothelial cell-specific receptor tyrosine kinase TIE in the mouse vasculature. Mouse embryos homozygous for a disrupted Tie allele developed severe edema, their microvasculature was ruptured and they died between days 13.5 and 14.5 of gestation. The major blood vessels...
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