The receptor tyrosine kinase TIE is required for integrity and survival of vascular endothelial cells.

doi:10.1002/j.1460-2075.1995.tb00276.x

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Article

The receptor tyrosine kinase TIE is required for integrity and survival of vascular endothelial cells.

The EMBO journal - 1 Dec 1995

Puri M C, Rossant J, Alitalo K, Bernstein A, Partanen J

Abstract excerpt

Vascular endothelial cells are critical for the development and function of the mammalian circulatory system. We have analyzed the role of the endothelial cell-specific receptor tyrosine kinase TIE in the mouse vasculature. Mouse embryos homozygous for a disrupted Tie allele developed severe edem...

Topics

Animals
Blotting, Southern
Cell Death
Cell Survival
Embryonic and Fetal Development
Endothelium, Vascular
Gene Targeting
Genes, Reporter
Genotype
Heterozygote
Histocytochemistry
Homozygote

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Kidney

Mice

Mice, Transgenic

Neovascularization, Physiologic

Receptor Protein-Tyrosine Kinases

Receptors, Cell Surface

Source

Open in PubMed Open full text

Identifiers

PMID: 8846781
DOI: 10.1002/j.1460-2075.1995.tb00276.x
PMCID: PMC394706

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8846781-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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The receptor tyrosine kinase TIE is required for integrity and survival of vascular endothelial cells.PMID 8846781Read ↗

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