Article
Expression of mutant TIE2 p.L914F during mouse development causes embryonic lethality and defects in vascular remodeling.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Sept 2026
Bischoff Lindsay J, Schrenk Sandra, Soroko Kara, Sherpa Chhiring, Arasu Ashok, Reynaud Damien, Boscolo Elisa
Abstract excerpt
BACKGROUND: Sporadic venous malformation (VM) is associated with the hyperactivating p.L914F mutation in TIE2, a receptor tyrosine kinase essential for vascular development. This mutation is not found in hereditary VM, suggesting incompatibility with life when expressed during early vascular development. Therefore, we utilized a genetic mouse model that expresses TIE2 p.L914F to determine its phenotypical effects...
Read the complete abstract on PubMedTopics
- Animals
- Receptor, TIE-2
- Mice
- Vascular Remodeling
- Mice, Transgenic
- Vascular Malformations