Article

Expression of mutant TIE2 p.L914F during mouse development causes embryonic lethality and defects in vascular remodeling

2025-07-30

Abstract excerpt

<h4>Background</h4> Sporadic venous malformation (VM) is associated with the hyperactivating p.L914F mutation in TIE2, a receptor tyrosine kinase essential for vascular development. This mutation is not found in hereditary VM, suggesting incompatibility with life when expressed during early vascular development. Therefore, we utilized a novel genetic mouse model that expresses TIE2 p.L914F to determine the phenot...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2e8f6995-b0a1-59fd-afc6-447fd6e19d22
DOI: 10.1101/2025.07.24.666614

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Expression of mutant TIE2 p.L914F during mouse development causes embryonic lethality and defects in vascular remodelingDOI 10.1101/2025.07.24.666614Read

Constitutive, mosaic expression of TIE2 p.L914F during mouse development causes formation of venous malformationSemantic proximity Read

Constitutive, Mosaic Expression of TIE2 p.L914F During Mouse Development Causes Venous Malformation.Semantic proximity Read

Mouse models of vascular development and diseaseSemantic proximity Read

Endothelial cell expression of mutant Map2k1 causes vascular malformations in mice.Semantic proximity Read

Vascular development: genetic mechanisms and links to vascular disease.Semantic proximity Read

Phenotypic Transition of Vascular Smooth Muscle Cells Induced by Endothelial TIE2 Mutations in Venous MalformationsSemantic proximity Read

Pathogenesis and molecular mechanisms of mutant TIE2-driven venous malformation.Semantic proximity Read

Somatic activating mutations in Pik3ca cause sporadic venous malformations in mice and humans.Semantic proximity Read

Arteriovenous malformation Map2k1 mutation affects vasculogenesis.Semantic proximity Read

Common and specific effects of TIE2 mutations causing venous malformations.Semantic proximity Read

Venous malformation-causative TIE2 mutations mediate an AKT-dependent decrease in PDGFBSemantic proximity Read

Constitutive Active Mutant TIE2 Induces Enlarged Vascular Lumen Formation with Loss of Apico-basal Polarity and Pericyte RecruitmentSemantic proximity Read