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Article

Evolutionary Duplication of a Hepatic Control Region in the Human Apolipoprotein E Gene Locus

1 Nov 1995

Abstract excerpt

We have identified a second hepatic control region (HCR-2) in the human apolipoprotein (apo) E gene locus that confers liver expression of the human apoE gene in transgenic mice. This HCR-2 sequence is located 27 kilobases downstream of the apoE gene and 10 kilobases downstream of the previously described liver-specific enhancer (HCR-1). Nucleotide sequence analysis of the HCR-2 region revealed a sequence that...

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Identifiers

PMID: 7592836
DOI: 10.1074/jbc.270.44.26278

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