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Article

Sequence diversity and functional characterization of the 5'-regulatory region of human CYP2C19.

Pharmacogenetics - 1 Apr 2003

Arefayene Million, Skaar Todd C, Zhao Xiaojiong, Rae James M, Tanus-Santos Jose E, Brinkmann Ulrich, Brehm Ilka, Salat Ulrike, Nguyen Anne, Desta Zeruesenay, Flockhart David A

Abstract excerpt

Cytochrome p4502C19 (CYP2C19) plays an important role in drug biotransformation and has been shown to be genetically polymorphic. While polymorphisms in the coding region that have large effects on activity are well described, until recently, a lack of knowledge of the promoter sequence has hindered efforts to study it. Genetic variants in the promoter region have not been described and factors that influence its...

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PMID: 12668916
DOI: 10.1097/00008571-200304000-00004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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