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Article

Identification and functional analysis of a novel human CYP2E1 far upstream enhancer.

Molecular pharmacology - 1 Jun 2007

Shadley Jeff D, Divakaran Karthika, Munson Kimber, Hines Ronald N, Douglas Kirk, McCarver D Gail

Abstract excerpt

Both transcriptional and post-transcriptional CYP2E1 regulatory mechanisms are known, resulting in 20-fold or greater variation in CYP2E1 expression. To evaluate functional regulatory elements controlling transcription, CYP2E1 promoter constructs were used to make adenovirus vectors containing CYP2E1 promoter-driven luciferase reporters for analyses in both primary human hepatocytes and HepG2 cells. A...

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Share to Cytochrome P-450 CYP2E1
Share to Enhancer Elements, Genetic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to GATA4 Transcription Factor

Share to Gene Expression Regulation, Enzymologic

Share to Hepatocytes

Share to Repetitive Sequences, Nucleic Acid

Share to Steroidogenic Factor 1

Share to Transcriptional Activation

Source

Identifiers

PMID: 17353354
DOI: 10.1124/mol.106.031302

Genes

GATA4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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