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Article

Genetic polymorphism of human CYP2E1: characterization of two variant alleles.

Molecular pharmacology - 1 Mar 1997

Hu Y, Oscarson M, Johansson I, Yue Q Y, Dahl M L, Tabone M, Arincò S, Albano E, Ingelman-Sundberg M

Abstract excerpt

Ethanol-inducible CYP2E1 is an enzyme of major toxicological interest because it metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. CYP2E1 has also been implicated in alcohol liver disease because of its contribution to oxidative stress. Previously, polymorphic alleles with mutations in introns and in the 5'-flanking regulatory region have been described, and their presence has been...

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PMID: 9058590

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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