Genetic polymorphism of human CYP2E1: characterization of two variant alleles.

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Article

Genetic polymorphism of human CYP2E1: characterization of two variant alleles.

Molecular pharmacology - 1 Mar 1997

Hu Y, Oscarson M, Johansson I, Yue Q Y, Dahl M L, Tabone M, Arincò S, Albano E, Ingelman-Sundberg M

Abstract excerpt

Ethanol-inducible CYP2E1 is an enzyme of major toxicological interest because it metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. CYP2E1 has also been implicated in alcohol liver disease because of its contribution to oxidative stress. Previously, polymorphic allel...

Topics

Alleles
Animals
Base Sequence
COS Cells
Chlorzoxazone
Cytochrome P-450 CYP2E1
Humans
Mutation
Point Mutation
Polymorphism, Genetic
Polymorphism, Single-Stranded Conformational
Sequence Analysis, DNA

Source

Open in PubMed

Identifiers

PMID: 9058590

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9058590-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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