Article
Catechol-O-methyltransferase polymorphisms and schizophrenia: a transmission disequilibrium study in multiply affected families.
Psychiatric genetics - 1 Jan 1997
Kunugi H, Vallada H P, Sham P C, Hoda F, Arranz M J, Li T, Nanko S, Murray R M, McGuffin P, Owen M, Gill M, Collier D A
Abstract excerpt
Catechol-O-methyltransferase (COMT) metabolizes catecholamines such as dopamines, noradrenaline and adrenaline. It exists as common high and low activity alleles in the population (determined by a valine 158 methionine polymorphisms), and high red blood cell activity of COMT has previously been associated with schizophrenia. To examine the relationship between COMT and schizophrenia genetically, the transmission...
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