Article
Family-based and case-control study of catechol-O-methyltransferase in schizophrenia among Palestinian Arabs.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 15 May 2003
Kremer I, Pinto M, Murad I, Muhaheed M, Bannoura I, Muller D J, Schulze T G, Reshef A, Blanaru M, Gathas S, Goichman R, Rietschel M, Dobrusin M, Bachner-Melman R, Nemanov L, Belmaker R H, Maier W, Ebstein R P
Abstract excerpt
COMT is a ubiquitous enzyme crucial to catechol metabolism. The molecular basis of COMT thermolability, that leads to three to fourfold differences in enzyme activity, is due to a substitution of valine with methionine in the Val158/108Met polymorphism. Of special interest is the role of this gene in major psychoses especially since a microdeletion (22q11) containing the COMT gene (velo-cardio-facial syndrome)...
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