Ki-ras activation in lung cells isolated from AC3F1 (A/J x C3H/HeJ) mice after treatment with aflatoxin B1.

doi:10.1002/(sici)1098-2744(199909)26:1<62::aid-mc8>3.0.co;2-u

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Article

Ki-ras activation in lung cells isolated from AC3F1 (A/J x C3H/HeJ) mice after treatment with aflatoxin B1.

Molecular carcinogenesis - 1 Sept 1999

Donnelly P J, Massey T E

Abstract excerpt

Lung cells isolated from AC3F1 (A/J x C3H/HeJ) mice 7 wk after treatment with the carcinogenic mycotoxin aflatoxin B1 (AFB1) were examined for point mutations in the Ki-ras oncogene. Ki-ras mutant allele frequencies in fractions enriched with nonciliated bronchiolar epithelial (Clara) cells were consistently higher than in alveolar type II cell fractions. Mutant alleles were undetectable or minimal in macrophage-...

Topics

Administration, Topical
Aflatoxin B1
Alleles
Animals
Anti-Inflammatory Agents
Carcinogens
Cell Separation
Dimethyl Sulfoxide
Epithelial Cells
Female
Gene Expression Regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genes, ras

Lung

Mice

Mice, Inbred A

Mice, Inbred C3H

Point Mutation

Source

Open in PubMed

Identifiers

PMID: 10487523
DOI: 10.1002/(sici)1098-2744(199909)26:1<62::aid-mc8>3.0.co;2-u

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