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Article

Activation of K-ras in aflatoxin B1-induced lung tumors from AC3F1 (A/J x C3H/HeJ) mice.

Carcinogenesis - 1 Aug 1996

Donnelly P J, Devereux T R, Foley J F, Maronpot R R, Anderson M W, Massey T E

Abstract excerpt

In addition to being a potent hepatocarcinogen, aflatoxin B1 (AFB1) is a pulmonary carcinogen in experimental animals and epidemiological studies have shown an association between AFB1 exposure and lung cancer in humans. Since point mutations at codons 12, 13 and 61 of the K-ras protooncogene are...

Topics

Aflatoxin B1
Alleles
Animals
Carcinogens
Female
Gene Expression Regulation, Neoplastic
Genes, ras
Genomic Imprinting
Lung Neoplasms
Mice
Mice, Inbred Strains
Polymerase Chain Reaction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single-Stranded Conformational

Source

Identifiers

PMID: 8761434
DOI: 10.1093/carcin/17.8.1735

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8761434-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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