Article
Activation of protooncogenes in mouse lung tumors.
Experimental lung research - 1 Jan 2000
You M, Wang Y, Lineen A, Stoner G D, You L A, Maronpot R R, Anderson M W
Abstract excerpt
The detection of activated protooncogenes in mouse lung tumors has led to a major advance in our understanding of carcinogenesis of the lung at the molecular level. A high frequency of activated K-ras protooncogenes has been detected in tetranitromethane (TNM)- and 1,3-butadiene-induced lung tumo...
Topics
- Animals
- Blotting, Southern
- DNA, Neoplasm
- Gene Amplification
- Gene Expression Regulation, Neoplastic
- Genes, ras
- Lung Neoplasms
- Mice
- Mice, Inbred A
- Mutation
- Proto-Oncogenes
- Transfection