Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Distinct roles of profilin in cell morphological changes: microspikes, membrane ruffles, stress fibers, and cytokinesis.

FEBS letters - 3 Sept 1999

Suetsugu S, Miki H, Takenawa T

Abstract excerpt

Here we report the functional importance of profilin in various actin-mediated morphological changes using H119E mutant profilin I, which is deficient only in actin binding. In the case of actin-protrusive structures from the plasma membrane, H119E-profilin was shown to suppress the formation of Cdc42-induced actin microspikes and Rac-induced membrane ruffles. Conversely, Rho-induced stress fiber formation seemed...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3T3 Cells
Share to cdc42 GTP-Binding Protein
Share to Contractile Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lysophospholipids

Share to Platelet-Derived Growth Factor

Share to Profilins

Share to rac GTP-Binding Proteins

Share to rho GTP-Binding Proteins

Source

Identifiers

PMID: 10471831
DOI: 10.1016/s0014-5793(99)01086-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Distinct roles of profilin in cell morphological changes: microspikes, membrane ruffles, stress fibers, and cytokinesis.PMID 10471831Read ↗

Profilin and actin-related proteins regulate microfilament dynamics during early mammalian embryogenesisSemantic proximity Read ↗

Fission yeast profilin is tailored to facilitate actin assembly by the cytokinesis formin Cdc12.Semantic proximity Read ↗

Unusual actin-binding mechanism and the role of profilin in actin dynamics of trypanosomatid parasitesSemantic proximity Read ↗

Profilin mutations disrupt multiple actin-dependent processes during Drosophila development.Semantic proximity Read ↗

Actin can reorganize into podosomes in aortic endothelial cells, a process controlled by Cdc42 and RhoA.Semantic proximity Read ↗

p190RhoGAP is cell cycle regulated and affects cytokinesis.Semantic proximity Read ↗

The loss of profilin1 is catastrophic to podocytesSemantic proximity Read ↗

Profilin1 is expressed in osteocytes and regulates cell shape and migration.Semantic proximity Read ↗

Incompatibility with formin Cdc12p prevents human profilin from substituting for fission yeast profilin: insights from crystal structures of fission yeast profilin.Semantic proximity Read ↗

Silencing profilin-1 inhibits endothelial cell proliferation, migration and cord morphogenesisSemantic proximity Read ↗

Profilin and Mical combine to impair F-actin assembly and promote disassembly and remodeling.Semantic proximity Read ↗

The transient appearance of zipper-like actin superstructures during the fusion of osteoclastsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.