Article
Profilin mutations disrupt multiple actin-dependent processes during Drosophila development.
Development (Cambridge, England) - 1 Apr 1994
Verheyen E M, Cooley L
Abstract excerpt
The chickadee gene of Drosophila encodes profilin, a small actin binding protein. We present the first analysis of the effects of profilin deletion in a multicellular organism. Genomic deletions of the chickadee locus result in a late embryonic lethal phenotype indicating that profilin is essenti...
Topics
- Actins
- Alleles
- Animals
- Blotting, Southern
- Contractile Proteins
- Drosophila
- Drosophila Proteins
- Female
- Gene Deletion
- Genes, Insect
- Microfilament Proteins
- Microscopy, Electron, Scanning
- Morphogenesis
- Oogenesis
- Phenotype
- Profilins