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Article

Profilin mutations disrupt multiple actin-dependent processes during Drosophila development.

Development (Cambridge, England) - 1 Apr 1994

Verheyen E M, Cooley L

Abstract excerpt

The chickadee gene of Drosophila encodes profilin, a small actin binding protein. We present the first analysis of the effects of profilin deletion in a multicellular organism. Genomic deletions of the chickadee locus result in a late embryonic lethal phenotype indicating that profilin is essential in flies. In addition, viable alleles of chickadee with defects in oogenesis, spermatogenesis and bristle formation...

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Identifiers

PMID: 7600952
DOI: 10.1242/dev.120.4.717

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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