Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Profilin and Mical combine to impair F-actin assembly and promote disassembly and remodeling.

Nature communications - 20 Sept 2021

Grintsevich Elena E, Ahmed Giasuddin, Ginosyan Anush A, Wu Heng, Rich Shannon K, Reisler Emil, Terman Jonathan R

Abstract excerpt

Cellular events require the spatiotemporal interplay between actin assembly and actin disassembly. Yet, how different factors promote the integration of these two opposing processes is unclear. In particular, cellular monomeric (G)-actin is complexed with profilin, which inhibits spontaneous actin nucleation but fuels actin filament (F-actin) assembly by elongation-promoting factors (formins, Ena/VASP). In...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Actin Cytoskeleton
Share to Cell Adhesion Molecules

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Formins

Share to Growth Cones

Share to Polymerization

Share to Profilins

Share to Rabbits

Share to Semaphorins

Source

Open in PubMed Open full text

Identifiers

PMID: 34545088
DOI: 10.1038/s41467-021-25781-3
PMCID: PMC8452626

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Profilin and Mical combine to impair F-actin assembly and promote disassembly and remodeling.PMID 34545088Read ↗

The spinal muscular atrophy gene product regulates actin dynamicsSemantic proximity Read ↗

Intermediate filament assembly: dynamics to disease.Semantic proximity Read ↗

Profilin Isoforms in Health and Disease – All the Same but DifferentSemantic proximity Read ↗

Molecular mechanism of actin filament elongation by formins.Semantic proximity Read ↗

Mena is required for neurulation and commissure formation.Semantic proximity Read ↗

Decoupling axonal regrowth and branching through Imp-dependent RNA regulation during neuronal remodelingSemantic proximity Read ↗

From structural resilience to cell specification - Intermediate filaments as regulators of cell fate.Semantic proximity Read ↗

Formin’ cellular structuresSemantic proximity Read ↗

Drosophila and human FHOD family formin proteins nucleate actin filamentsSemantic proximity Read ↗

Defining functional interactions during biogenesis of epithelial junctions.Semantic proximity Read ↗

MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion.Semantic proximity Read ↗

Proper cellular reorganization during Drosophila spermatid individualization depends on actin structures composed of two domains, bundles and meshwork, that are differentially regulated and have different functions.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.