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Article

Fission yeast profilin is tailored to facilitate actin assembly by the cytokinesis formin Cdc12.

Molecular biology of the cell - 15 Jan 2015

Bestul Andrew J, Christensen Jenna R, Grzegorzewska Agnieszka P, Burke Thomas A, Sees Jennifer A, Carroll Robert T, Sirotkin Vladimir, Keenan Robert J, Kovar David R

Abstract excerpt

The evolutionarily conserved small actin-monomer binding protein profilin is believed to be a housekeeping factor that maintains a general pool of unassembled actin. However, despite similar primary sequences, structural folds, and affinities for G-actin and poly-L-proline, budding yeast profilin ScPFY fails to complement fission yeast profilin SpPRF temperature-sensitive mutant cdc3-124 cells. To identify...

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Identifiers

PMID: 25392301
DOI: 10.1091/mbc.E13-05-0281
PMCID: PMC4294675

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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