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Silencing profilin-1 inhibits endothelial cell proliferation, migration and cord morphogenesis

13 Sept 2006

Abstract excerpt

Expression of several actin-binding proteins including profilin-1 is up-regulated during capillary morphogenesis of endothelial cells, the biological significance of which remains unknown. Specifically, we hypothesized that profilin-1 is important for endothelial migration and proliferation. In this study, we suppressed profilin-1 expression in human umbilical vein endothelial cells by RNA-interference. Gene...

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PMID: 16968742
DOI: 10.1242/jcs.03178

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