Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

p190RhoGAP is cell cycle regulated and affects cytokinesis.

The Journal of cell biology - 10 Nov 2003

Su Ling, Agati Joyce M, Parsons Sarah J

Abstract excerpt

p190RhoGAP (p190), a Rho family GTPase-activating protein, regulates actin stress fiber dynamics via hydrolysis of Rho-GTP. Recent data suggest that p190 also regulates cell proliferation. To gain insights into the cellular process(es) affected by p190, we altered its levels by conditional or transient overexpression. Overexpression of p190 resulted in a multinucleated phenotype that was dependent on the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma
Share to Cell Cycle Proteins
Share to Cell Nucleus

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Down-Regulation

Share to GTPase-Activating Proteins

Share to Guanine Nucleotide Exchange Factors

Share to Repressor Proteins

Share to Ubiquitin

Source

Open in PubMed Open full text

Identifiers

PMID: 14610059
DOI: 10.1083/jcb.200308007
PMCID: PMC2173658

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

p190RhoGAP is cell cycle regulated and affects cytokinesis.PMID 14610059Read ↗

A complex of p190RhoGAP-A and anillin modulates RhoA-GTP and the cytokinetic furrow in human cells.Semantic proximity Read ↗

FAM190A deficiency creates a cell division defect.Semantic proximity Read ↗

p190A inactivating mutations cause aberrant RhoA activation and promote malignant transformation via the Hippo-YAP pathway in endometrial cancer.Semantic proximity Read ↗

The degradation of two mitotic cyclins contributes to the timing of cytokinesis.Semantic proximity Read ↗

Roles of Rho-associated kinase in cytokinesis; mutations in Rho-associated kinase phosphorylation sites impair cytokinetic segregation of glial filaments.Semantic proximity Read ↗

Megakaryocyte endomitosis is a failure of late cytokinesis related to defects in the contractile ring and Rho/Rock signalingSemantic proximity Read ↗

P190-B Rho GTPase-activating protein overexpression disrupts ductal morphogenesis and induces hyperplastic lesions in the developing mammary gland.Semantic proximity Read ↗

Cell cycle-independent furrowing triggered by phosphomimetic mutations of the INCENP STD motif requires Plk1.Semantic proximity Read ↗

miR-190 is a Key Regulator in Establishing Cell Polarity and Specification in the Drosophila Nervous SystemSemantic proximity Read ↗

Mechanisms for concentrating Rho1 during cytokinesis.Semantic proximity Read ↗

Inhibition of cyclin-dependent kinase 1 induces cytokinesis without chromosome segregation in an ECT2 and MgcRacGAP-dependent manner.Semantic proximity Read ↗

Identification of an inhibitory domain in GTPase-activating protein p190RhoGAP responsible for masking its functional GAP domain.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.