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Article

The loss of profilin1 is catastrophic to podocytes

14 Dec 2023

Abstract excerpt

Profilin1 belongs to a family of small monomeric actin-binding proteins with diverse roles in fundamental actin-dependent cellular processes required for cell survival. Podocytes are postmitotic visceral epithelial cells critical for the structure and function of the kidney filtration barrier. There is emerging evidence that the actin-related mode of cell death known as mitotic catastrophe is an important pathway...

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PMID: 38099501
DOI: 10.1172/jci175594

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