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Article

Profilin and actin-related proteins regulate microfilament dynamics during early mammalian embryogenesis

20 Jan 2006

Abstract excerpt

BACKGROUND: Profilins are ubiquitous proteins widely distributed in animals, including humans. They regulate actin polymerization by sequestering actin monomers in association with other actin-related proteins (Arps). Actin remodelling is essential for oocyte maturation, fertilization and embryo development; yet the role of profilins in these events is not well understood. Here we investigate profilin...

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PMID: 16428331
DOI: 10.1093/humrep/dei480

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