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Article

Incompatibility with formin Cdc12p prevents human profilin from substituting for fission yeast profilin: insights from crystal structures of fission yeast profilin.

The Journal of biological chemistry - 23 Jan 2009

Ezezika Obidimma C, Younger Noah S, Lu Jia, Kaiser Donald A, Corbin Zachary A, Nolen Bradley J, Kovar David R, Pollard Thomas D

Abstract excerpt

Expression of human profilin-I does not complement the temperature-sensitive cdc3-124 mutation of the single profilin gene in fission yeast Schizosaccharomyces pombe, resulting in death from cytokinesis defects. Human profilin-I and S. pombe profilin have similar affinities for actin monomers, th...

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Identifiers

PMID: 19028693
DOI: 10.1074/jbc.M807073200
PMCID: PMC2629104

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19028693-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Incompatibility with formin Cdc12p prevents human profilin from substituting for fission yeast profilin: insights from crystal structures of fission yeast profilin.PMID 19028693Read ↗

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