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Article

The transient appearance of zipper-like actin superstructures during the fusion of osteoclasts

1 Feb 2012

Abstract excerpt

Multinucleated osteoclasts are responsible for bone resorption. Hypermultinucleated osteoclasts are often observed in some bone-related diseases such as Paget's disease and cherubism. The cellular mechanics controlling the size of osteoclasts is poorly understood. We introduced EGFP-actin into RAW 264.7 cells to monitor actin dynamics during osteoclast differentiation. Before their terminal differentiation into...

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PMID: 22349694
DOI: 10.1242/jcs.090886

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