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Article

Heterologous expression, purification, reconstitution and kinetic analysis of an extended type II polyketide synthase.

Chemistry & biology - 1 Sept 1999

Zawada R J, Khosla C

Abstract excerpt

BACKGROUND: Polyketide synthases (PKSs) are bacterial multienzyme systems that synthesize a broad range of natural products. The 'minimal' PKS consists of a ketosynthase, a chain length factor, an acyl carrier protein and a malonyl transferase. Auxiliary components (ketoreductases, aromatases and cyclases are involved in controlling the oxidation level and cyclization of the nascent polyketide chain. We describe...

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Identifiers

PMID: 10467128
DOI: 10.1016/s1074-5521(99)80112-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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