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Article

Genetic construction and functional analysis of hybrid polyketide synthases containing heterologous acyl carrier proteins.

Journal of bacteriology - 1 Apr 1993

Khosla C, McDaniel R, Ebert-Khosla S, Torres R, Sherman D H, Bibb M J, Hopwood D A

Abstract excerpt

The gene that encodes the acyl carrier protein (ACP) of the actinorhodin polyketide synthase (PKS) of Streptomyces coelicolor A3(2) was replaced with homologs from the granaticin, oxytetracycline, tetracenomycin, and putative frenolicin polyketide synthase gene clusters. All of the replacements led to expression of functional synthases, and the recombinants synthesized aromatic polyketides similar in...

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Identifiers

PMID: 8468280
DOI: 10.1128/jb.175.8.2197-2204.1993
PMCID: PMC204504

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