Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Partial <i>In Vitro</i> Reconstitution of an Orphan Polyketide Synthase Associated with Clinical Cases of Nocardiosis

6 Jul 2016

Abstract excerpt

Although a few well-characterized polyketide synthases (PKSs) have been functionally reconstituted in vitro from purified protein components, the use of this strategy to decode "orphan" assembly line PKSs has not been described. To begin investigating a PKS found only in Nocardia strains associated with clinical cases of nocardiosis, we reconstituted in vitro its five terminal catalytic modules. In the presence...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Actinomycetales infections and treatment
Share to Fungal Infections and Studies
Share to Infectious Diseases and Mycology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27384917
DOI: 10.1021/acschembio.6b00489

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Partial <i>In Vitro</i> Reconstitution of an Orphan Polyketide Synthase Associated with Clinical Cases of NocardiosisPMID 27384917Read ↗

Complete Reconstitution and Deorphanization of the 3 MDa NOCAP (NOCardiosis-Associated Polyketide) SynthaseSemantic proximity Read ↗

Complete Reconstitution and Deorphanization of the 3 MDa Nocardiosis-Associated Polyketide SynthaseSemantic proximity Read ↗

Discovery and Characterization of the Fully Decorated Nocardiosis-Associated Polyketide Natural ProductSemantic proximity Read ↗

Heterologous expression, purification, reconstitution and kinetic analysis of an extended type II polyketide synthase.Semantic proximity Read ↗

Crystal structure of a bacterial type III polyketide synthase and enzymatic control of reactive polyketide intermediates.Semantic proximity Read ↗

Biosynthesis of mycobacterial lipids by polyketide synthases and beyondSemantic proximity Read ↗

Genome based analysis of type-I polyketide synthase and nonribosomal peptide synthetase gene clusters in seven strains of five representative Nocardia speciesSemantic proximity Read ↗

Identification of a cryptic type III polyketide synthase (1,3,6,8-tetrahydroxynaphthalene synthase) from Streptomyces peucetius ATCC 27952.Semantic proximity Read ↗

Unravelling the functional diversity of type III polyketide synthases in fungiSemantic proximity Read ↗

Elucidating the molecular programming of a nonlinear nonribosomal peptide synthetase responsible for fungal siderophore biosynthesisSemantic proximity Read ↗

Identification of a bioactive 51-membered macrolide complex by activation of a silent polyketide synthase in <i>Streptomyces ambofaciens</i>Semantic proximity Read ↗

A novel group of type I polyketide synthases (PKS) in animals and the complex phylogenomics of PKSsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.