Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Heterologous Biosynthesis of Type II Polyketide Products Using E. coli.

ACS chemical biology - 15 May 2020

Liu Xiangyang, Hua Kangmin, Liu Dongxu, Wu Zhen-Long, Wang Ying, Zhang Haoran, Deng Zixin, Pfeifer Blaine A, Jiang Ming

Abstract excerpt

The heterologous biosynthesis of complex natural products has enabled access to polyketide, nonribosomal peptide, isoprenoid, and other compounds with wide-spanning societal value. Though several surrogate host systems exist, Escherichia coli is often a preferred choice due to its rapid growth kinetics and extensive molecular biology protocols. However, a persistent challenge to the utilization of E. coli has...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anthraquinones
Share to Biological Products

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Escherichia coli Proteins

Share to Gene Expression Regulation, Bacterial

Share to Isoquinolines

Share to Naphthoquinones

Share to Polyketide Synthases

Share to Protein Multimerization

Source

Identifiers

PMID: 31825590
DOI: 10.1021/acschembio.9b00827

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Heterologous Biosynthesis of Type II Polyketide Products Using E. coli.PMID 31825590Read ↗

Metabolic Engineering and Synthetic Biology Approaches for the Heterologous Production of Aromatic PolyketidesSemantic proximity Read ↗

Steps towards the synthetic biology of polyketide biosynthesisSemantic proximity Read ↗

POLYKETIDE SYNTHASE GENE MANIPULATION: A Structure-Function Approach in Engineering Novel AntibioticsSemantic proximity Read ↗

Combinatorialization of fungal polyketide synthase-peptide synthetase hybrid proteins.Semantic proximity Read ↗

Poly specific trans-acyltransferase machinery revealed via engineered acyl-CoA synthetases.Semantic proximity Read ↗

Heterologous Production and Yield Improvement of Epothilones in Burkholderiales Strain DSM 7029Semantic proximity Read ↗

Heterologous expression, purification, reconstitution and kinetic analysis of an extended type II polyketide synthase.Semantic proximity Read ↗

Biotechnology of polyketides: new breath of life for the novel antibiotic genetic pathways discovery through metagenomicsSemantic proximity Read ↗

Structural and biochemical analyses of regio- and stereospecificities observed in a type II polyketide ketoreductase.Semantic proximity Read ↗

Pathway engineering in yeast for synthesizing the complex polyketide bikaverinSemantic proximity Read ↗

The determinants of activity and specificity in actinorhodin type II polyketide ketoreductase.Semantic proximity Read ↗

[Controlled biosynthesis of polyketide antibiotics].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.