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POLYKETIDE SYNTHASE GENE MANIPULATION: A Structure-Function Approach in Engineering Novel Antibiotics

1 Oct 1995

Abstract excerpt

Polyketides are produced primarily in microorganisms through a specialized metabolism that is a variation of fatty acid biosynthesis. A strong sequence and mechanistic similarity among many of the fatty acid and polyketide synthase enzymes has led to two paradigms for explaining polyketide biochemistry. In one, polyketides are formed by enzyme complexes consisting of four to seven monofunctional proteins in which...

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Computational Drug Discovery Methods
Microbial Metabolism and Applications
Microbial Natural Products and Biosynthesis

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 8561459
DOI: 10.1146/annurev.mi.49.100195.001221

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