Article

Complete Reconstitution and Deorphanization of the 3 MDa NOCAP (NOCardiosis-Associated Polyketide) Synthase

2020-01-29

Abstract excerpt

<h4>ABSTRACT</h4> Several Nocardia strains associated with nocardiosis, a potentially life-threatening disease, house a nonamodular assembly-line polyketide synthase (PKS) that presumably synthesizes an unknown natural product. Here, we report the discovery and structure elucidation of the NOCAP (NOCardiosis-Associated Polyketide) aglycone by first fully reconstituting the NOCAP synthase in vitro from purified...

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Literature Corpus work: f9e27d22-b7a8-5b27-a98d-75c6b99b6f27
DOI: 10.1101/2020.01.28.923383

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