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Complete Reconstitution and Deorphanization of the 3 MDa Nocardiosis-Associated Polyketide Synthase

17 Mar 2020

Abstract excerpt

Several Nocardia strains associated with nocardiosis, a potentially life-threatening disease, house a nonamodular assembly line polyketide synthase (PKS) that presumably synthesizes an unknown polyketide. Here, we report the discovery and structure elucidation of the NOCAP (nocardiosis-associated polyketide) aglycone by first fully reconstituting the NOCAP synthase in vitro from purified protein components...

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PMID: 32182063
DOI: 10.1021/jacs.0c00904

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