Deficient assembly and function of gap junctions in Trf1, a trafficking mutant of the human liver-derived cell line HuH-7.

doi:10.1002/hep.510300304

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Article

Deficient assembly and function of gap junctions in Trf1, a trafficking mutant of the human liver-derived cell line HuH-7.

Hepatology (Baltimore, Md.) - 1 Sept 1999

Stockert R J, Spray D C, Gao Y, Suadicani S O, Ripley C R, Novikoff P M, Wolkoff A W, Hertzberg E L

Abstract excerpt

The Trf1 cell line, selected from the human hepatoma cell line HuH-7, manifests altered trafficking of various plasma membrane proteins. In particular, there is a striking loss of State 2 asialoglycoprotein receptors. This cell line is shown here to also manifest defects in function and assembly of gap junctions comprising connexin43 (Cx43). No alteration of Cx43 expression or phosphorylation was apparent....

Topics

Asialoglycoprotein Receptor
Calcium
Cell Communication
Connexin 43
Gap Junctions
Humans
Liver
Membrane Proteins
Mutation
Receptors, Cell Surface
Tumor Cells, Cultured

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Open in PubMed

Identifiers

PMID: 10462381
DOI: 10.1002/hep.510300304

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