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Article

Disruption of PDGF receptor trafficking by mutation of its PI-3 kinase binding sites.

Science (New York, N.Y.) - 4 Feb 1994

Joly M, Kazlauskas A, Fay F S, Corvera S

Abstract excerpt

Human platelet-derived growth factor receptors (PDGFRs) expressed in human Hep G2 cells internalized and concentrated in a juxtanuclear region near the Golgi network within 10 minutes after the cells were treated with PDGF. A PDGFR mutant (F5) that lacks high-affinity binding sites for the Src homology 2 domain-containing proteins phosphatidylinositol-3 kinase (PI-3 kinase), Ras guanosine triphosphatase...

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Identifiers

PMID: 8303278
DOI: 10.1126/science.8303278

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Disruption of PDGF receptor trafficking by mutation of its PI-3 kinase binding sites.PMID 8303278Read ↗

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