Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human liver cell trafficking mutants: characterization and whole exome sequencing.

PloS one - 1 Jan 2014

Yuan Fei, Snapp Erik L, Novikoff Phyllis M, Suadicani Sylvia O, Spray David C, Potvin Barry, Wolkoff Allan W, Stanley Pamela

Abstract excerpt

The HuH7 liver cell mutant Trf1 is defective in membrane trafficking and is complemented by the casein kinase 2α subunit CK2α''. Here we identify characteristic morphologies, trafficking and mutational changes in six additional HuH7 mutants Trf2-Trf7. Trf1 cells were previously shown to be severely defective in gap junction functions. Using a Lucifer yellow transfer assay, remarkable attenuation of gap junction...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Hepatocellular
Share to Cell Communication

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Endocytosis

Share to Gap Junctions

Share to rab GTP-Binding Proteins

Share to RNA, Small Interfering

Share to Transferrin

Source

Open in PubMed Open full text

Identifiers

PMID: 24466322
DOI: 10.1371/journal.pone.0087043
PMCID: PMC3900707

Genes

RAB22A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human liver cell trafficking mutants: characterization and whole exome sequencing.PMID 24466322Read ↗

Traffic Jam: A Compendium of Human Diseases that Affect Intracellular Transport ProcessesSemantic proximity Read ↗

Human iPSC-derived hepatocyte system models cholestasis with tight junction protein 2 deficiencySemantic proximity Read ↗

Traffic jams II: an update of diseases of intracellular transport.Semantic proximity Read ↗

Deficient assembly and function of gap junctions in Trf1, a trafficking mutant of the human liver-derived cell line HuH-7.Semantic proximity Read ↗

Targeting and trafficking of the human thiamine transporter-2 in epithelial cells.Semantic proximity Read ↗

Naturally Occurring Shorter and Tumor-associated Mutant RNF167 Variants Facilitates Lysosomal Exocytosis and Plasma Membrane ResealingSemantic proximity Read ↗

Human hepatoma cell mutant defective in cell surface protein trafficking.Semantic proximity Read ↗

Critical roles for the COOH terminus of the Cu-ATPase ATP7B in protein stability, trans-Golgi network retention, copper sensing, and retrograde trafficking.Semantic proximity Read ↗

Mutant-specific dysfunction of RHOBTB2 impairs mitochondrial function and Na+/K+-ATPase levels in a cell model.Semantic proximity Read ↗

Disrupted plasma membrane localization and loss of function reveal regions of human equilibrative nucleoside transporter 1 involved in structural integrity and activity.Semantic proximity Read ↗

Bridge-like lipid transfer protein family member 2 suppresses ciliogenesisSemantic proximity Read ↗

LRRK2 deficiency impairs trans-Golgi to lysosome trafficking and endocytic cargo degradation in human renal proximal tubule epithelial cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.