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Article

Differential effects of polyoma virus middle tumor antigen mutants upon gap junctional, intercellular communication.

Experimental cell research - 15 Aug 2015

Geletu Mulu, Guy Stephanie, Greer Samantha, Raptis Leda

Abstract excerpt

Gap junctions are channels that connect the cytoplasm of adjacent cells. Oncogenes such as the middle Tumor antigen of polyoma virus (mT) are known to suppress gap junctional, intercellular communication (GJIC). mT associates with and is tyrosine-phosphorylated by cSrc family members. Specific mT phosphotyrosines provide docking sites for the phosphotyrosine binding domain of Shc (mT-tyr250) or the SH2 domain of...

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PMID: 26187405
DOI: 10.1016/j.yexcr.2015.07.013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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