The receptor-recycling and lysosome biogenesis mutant TfT1.11 belongs to a new complementation group, End6.

doi:10.1007/BF02257485

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Article

The receptor-recycling and lysosome biogenesis mutant TfT1.11 belongs to a new complementation group, End6.

Somatic cell and molecular genetics - 1 Jan 1994

Bucci M, Moyer T W, Brown C M, Wilson R B, Murphy R F

Abstract excerpt

We have previously isolated a Chinese hamster ovary (CHO) mutant with a temperature-dependent pleiotropic defect in receptor recycling. This mutant, TfT1.11, has also been shown to have defects in fluid-phase endocytosis and lysosome biogenesis. Previously isolated CHO cell mutants with defects i...

Topics

Animals
CHO Cells
Cricetinae
Cricetulus
Endocytosis
Genes, Lethal
Genetic Complementation Test
Hybrid Cells
Lysosomes
Mutation
Phenotype
Receptors, Transferrin

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