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Article

Phosphorylation on Ser-279 and Ser-282 of connexin43 regulates endocytosis and gap junction assembly in pancreatic cancer cells.

Molecular biology of the cell - 1 Mar 2013

Johnson Kristen E, Mitra Shalini, Katoch Parul, Kelsey Linda S, Johnson Keith R, Mehta Parmender P

Abstract excerpt

The molecular mechanisms regulating the assembly of connexins (Cxs) into gap junctions are poorly understood. Using human pancreatic tumor cell lines BxPC3 and Capan-1, which express Cx26 and Cx43, we show that, upon arrival at the cell surface, the assembly of Cx43 is impaired. Connexin43 fails to assemble, because it is internalized by clathrin-mediated endocytosis. Assembly is restored upon expressing a...

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Identifiers

PMID: 23363606
DOI: 10.1091/mbc.E12-07-0537
PMCID: PMC3596244

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EEA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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