Article
Post-transcriptional regulation of the DNA damage-inducible gadd45 gene in human breast carcinoma cells exposed to a novel retinoid CD437.
Nucleic acids research - 1 Aug 1999
Rishi A K, Sun R J, Gao Y, Hsu C K, Gerald T M, Sheikh M S, Dawson M I, Reichert U, Shroot B, Fornace A J, Brewer G, Fontana J A
Abstract excerpt
The biologically active synthetic retinoid CD437 (6-[3-adamantyl-4-hydroxyphenyl]-2-naphthalene, AHPN) and different human breast carcinoma (HBC) cell lines were used to examine the possible mechanism(s) of gadd45 induction. Northern blot analysis of mRNA isolated from MCF-7, MDA-MB-468 and MDA-MB-231 HBC cell lines demonstrated a progressive increase in the 1.4 kb gadd45 transcript after exposure to 1 microM...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.