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Article

The stress-responsive gene GADD45G is a functional tumor suppressor, with its response to environmental stresses frequently disrupted epigenetically in multiple tumors.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Sept 2005

Ying Jianming, Srivastava Gopesh, Hsieh Wen-Son, Gao Zifen, Murray Paul, Liao Shuen-Kuei, Ambinder Richard, Tao Qian

Abstract excerpt

The CpG island of GADD45G was identified as a target sequence during the identification of hypermethylated genes using methylation-sensitive representational difference analysis combined with 5-aza-2'-deoxycytidine demethylation. Located at the commonly deleted region 9q22, GADD45G is a member of the DNA damage-inducible gene family. In response to stress shock, GADD45G inhibits cell growth and induces apoptosis....

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Identifiers

PMID: 16166418
DOI: 10.1158/1078-0432.CCR-05-0267

Genes

DNMT1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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