Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterization of human Gadd45, a p53-regulated protein.

1 Dec 1994

Abstract excerpt

GADD45 (growth arrest and DNA damage) is a DNA-damage-inducible gene regulated in part by the tumor suppressor p53. A role in negative growth control has recently been suggested based on significant (more than 75%) reduction of colony formation following over expression of Gadd45. To better understand the role of Gadd45, we have developed specific rabbit and murine antibodies raised against the human recombinant...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Cancer Research and Treatments
Share to Ubiquitin and proteasome pathways

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 7798274
DOI: 10.1016/s0021-9258(18)31687-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of human Gadd45, a p53-regulated protein.PMID 7798274Read ↗

Characterization of the GADD45 response to ionizing radiation in WI-L2-NS cells, a p53 mutant cell line.Semantic proximity Read ↗

Gadd45 mutations are uncommon in human tumour cell lines.Semantic proximity Read ↗

The <i>gadd</i> and <i>MyD</i> Genes Define a Novel Set of Mammalian Genes Encoding Acidic Proteins That Synergistically Suppress Cell GrowthSemantic proximity Read ↗

GADD45 induction of a G <sub>2</sub> /M cell cycle checkpointSemantic proximity Read ↗

The stress-responsive gene GADD45G is a functional tumor suppressor, with its response to environmental stresses frequently disrupted epigenetically in multiple tumors.Semantic proximity Read ↗

Induction by ionizing radiation of the gadd45 gene in cultured human cells: lack of mediation by protein kinase C.Semantic proximity Read ↗

Growth arrest and DNA damage-inducible 45: a new player on inflammatory diseasesSemantic proximity Read ↗

Induction of cellular p53 activity by DNA-damaging agents and growth arrest.Semantic proximity Read ↗

The gadd and MyD genes define a novel set of mammalian genes encoding acidic proteins that synergistically suppress cell growth.Semantic proximity Read ↗

Tumor Suppressor p53 Can Participate in Transcriptional Induction of the <i>GADD45</i> Promoter in the Absence of Direct DNA BindingSemantic proximity Read ↗

Clinicopathological significance of abnormalities in Gadd45 expression and its relationship to p53 in human pancreatic cancer.Semantic proximity Read ↗

A polymorphism but no mutations in the GADD45 gene in breast cancers.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.