Tumor Suppressor p53 Can Participate in Transcriptional Induction of the <i>GADD45</i> Promoter in the Absence of Direct DNA Binding

Abstract excerpt

The GADD45 gene is a growth arrest-associated gene that is induced by certain DNA-damaging agents and other stresses, such as starvation, in all mammalian cells. In addition to a strong p53-binding element in an intronic sequence, we have recently found that p53, while not required or sufficient alone, may contribute to the stress responsiveness of the promoter. Much of the responsiveness was localized to a...

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