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Article

Hypermethylation of growth arrest DNA damage-inducible gene 45 beta promoter in human hepatocellular carcinoma.

The American journal of pathology - 1 Nov 2004

Qiu Weihua, Zhou Bingsen, Zou Hongzhi, Liu Xiyong, Chu Peiguo G, Lopez Richard, Shih Jennifer, Chung Christopher, Yen Yun

Abstract excerpt

Growth arrest DNA damage-inducible gene 45 beta (GADD45beta) has been known to regulate cell growth, apoptotic cell death, and cellular response to DNA damage. Down-regulation of GADD45beta has been verified to be specific in hepatocellular cancer (HCC) and consistent with the p53 mutant, and degree of malignancy of HCC. This observation was further confirmed by eight HCC cell lines and paired human normal and...

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Identifiers

PMID: 15509538
DOI: 10.1016/s0002-9440(10)63425-6
PMCID: PMC1618679

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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