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Article

Induction of the p53-target gene GADD45 in HPV-positive cancer cells.

Oncogene - 8 Apr 1999

Butz K, Whitaker N, Denk C, Ullmann A, Geisen C, Hoppe-Seyler F

Abstract excerpt

The E6 oncoprotein of human papillomaviruses (HPVs) has the potential to functionally antagonize p53. In several experimental model systems, ectopic expression of E6 can block the genotoxic induction of the growth inhibitory p53 target gene gadd45, suggesting that the inactivation of this pathway may play a major role for HPV-associated cell transformation. Here, we investigated whether this reflects the...

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PMID: 10327059
DOI: 10.1038/sj.onc.1202557

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Induction of the p53-target gene GADD45 in HPV-positive cancer cells.PMID 10327059Read ↗

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A polymorphism but no mutations in the GADD45 gene in breast cancers.Semantic proximity Read ↗

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