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Article

Telomerase-independent proliferation is influenced by cell type in Saccharomyces cerevisiae.

Genetics - 1 Jul 2003

Lowell Joanna E, Roughton Alexander I, Lundblad Victoria, Pillus Lorraine

Abstract excerpt

Yeast strains harboring mutations in genes required for telomerase function (TLC1 and the EST genes) exhibit progressive shortening of telomeric DNA and replicative senescence. A minority of cells withstands loss of telomerase through RAD52-dependent amplification of telomeric and subtelomeric sequences; such survivors are now capable of long-term propagation with telomeres maintained by recombination rather than...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Mating Type, Fungal

Share to Rad52 DNA Repair and Recombination Protein

Share to Silent Information Regulator Proteins, Saccharomyces cerevisiae

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Source

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Identifiers

PMID: 12871903
DOI: 10.1093/genetics/164.3.909
PMCID: PMC1462614

Genes

RAD52

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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