Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Two survivor pathways that allow growth in the absence of telomerase are generated by distinct telomere recombination events.

Molecular and cellular biology - 1 Mar 2001

Chen Q, Ijpma A, Greider C W

Abstract excerpt

Yeast cells can survive in the absence of telomerase RNA, TLC1, by recombination-mediated telomere elongation. Two types of survivors, type I and type II, can be distinguished by their characteristic telomere patterns. RAD52 is essential for the generation of both types of survivors. Deletion of both RAD50 and RAD51 produces a phenotype similar to that produced by deletion of RAD52. Here we examined the effects...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blotting, Southern
Share to Epistasis, Genetic
Share to Fungal Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutagenesis

Share to Rad51 Recombinase

Share to Rad52 DNA Repair and Recombination Protein

Share to Telomerase

Share to Telomere

Source

Open in PubMed Open full text

Identifiers

PMID: 11238918
DOI: 10.1128/MCB.21.5.1819-1827.2001
PMCID: PMC86745

Genes

RAD51
RAD52
RAD50

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Two survivor pathways that allow growth in the absence of telomerase are generated by distinct telomere recombination events.PMID 11238918Read ↗

RAD50 and RAD51 define two pathways that collaborate to maintain telomeres in the absence of telomerase.Semantic proximity Read ↗

Telomerase-independent proliferation is influenced by cell type in Saccharomyces cerevisiae.Semantic proximity Read ↗

Telomere maintenance and survival in saccharomyces cerevisiae in the absence of telomerase and RAD52.Semantic proximity Read ↗

Telomere-Telomere Recombination Is an Efficient Bypass Pathway for Telomere Maintenance in <i>Saccharomyces cerevisiae</i>Semantic proximity Read ↗

Telomerase, the recombination machinery and Rap1 play redundant roles in yeast telomere protection.Semantic proximity Read ↗

Multiple Rad52-Mediated Homology-Directed Repair Mechanisms Are Required to Prevent Telomere Attrition-Induced Senescence in Saccharomyces cerevisiae.Semantic proximity Read ↗

Sgs1 RecQ helicase inhibits survival of Saccharomyces cerevisiae cells lacking telomerase and homologous recombination.Semantic proximity Read ↗

Recruitment of Rad51 and Rad52 to short telomeres triggers a Mec1-mediated hypersensitivity to double-stranded DNA breaks in senescent budding yeast.Semantic proximity Read ↗

Control of the yeast telomeric senescence survival pathways of recombination by the Mec1 and Mec3 DNA damage sensors and RPA.Semantic proximity Read ↗

The telotype defines the telomere state in Saccharomyces cerevisiae and is inherited as a dominant non-Mendelian characteristic in cells lacking telomerase.Semantic proximity Read ↗

Recombination and the Tel1 and Mec1 checkpoints differentially effect genome rearrangements driven by telomere dysfunction in yeast.Semantic proximity Read ↗

SGS1 is required for telomere elongation in the absence of telomerase.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.