TEL1, a gene involved in controlling telomere length in S. cerevisiae, is homologous to the human ataxia telangiectasia gene.

doi:10.1016/0092-8674(95)90479-4

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Article

TEL1, a gene involved in controlling telomere length in S. cerevisiae, is homologous to the human ataxia telangiectasia gene.

Cell - 8 Sept 1995

Greenwell P W, Kronmal S L, Porter S E, Gassenhuber J, Obermaier B, Petes T D

Abstract excerpt

Yeast chromosomes terminate in tracts of simple repetitive DNA (poly[G1-3T]). Mutations in the gene TEL1 result in shortened telomeres. Sequence analysis of TEL1 indicates that it encodes a very large (322 kDa) protein with amino acid motifs found in phosphatidylinositol/protein kinases. The clos...

Topics

Chromosomes
Cloning, Molecular
Genes, Fungal
Humans
Mitosis
Molecular Sequence Data
Mutation
Saccharomyces cerevisiae
Sequence Homology, Amino Acid
Telomere

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