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Article

RAD50 and RAD51 define two pathways that collaborate to maintain telomeres in the absence of telomerase.

Genetics - 1 May 1999

Le S, Moore J K, Haber J E, Greider C W

Abstract excerpt

Telomere length is maintained by the de novo addition of telomere repeats by telomerase, yet recombination can elongate telomeres in the absence of telomerase. When the yeast telomerase RNA component, TLC1, is deleted, telomeres shorten and most cells die. However, gene conversion mediated by the RAD52 pathway allows telomere lengthening in rare survivor cells. To further investigate the role of recombination in...

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Share to DNA Repair Enzymes
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Rad52 DNA Repair and Recombination Protein

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Source

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Identifiers

PMID: 10224249
DOI: 10.1093/genetics/152.1.143
PMCID: PMC1460580

Genes

RAD50
RAD51
RAD52

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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RAD50 and RAD51 define two pathways that collaborate to maintain telomeres in the absence of telomerase.PMID 10224249Read ↗

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