Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Article

Partial rescue of postnatal growth plate abnormalities in Ihh mutants by expression of a constitutively active PTH/PTHrP receptor.

Bone - 1 Feb 2010

Maeda Yukiko, Schipani Ernestina, Densmore Michael J, Lanske Beate

Abstract excerpt

Indian hedgehog (Ihh) is essential for chondrocyte proliferation/differentiation and osteoblast differentiation during prenatal endochondral bone formation. Ihh expression in postnatal chondrocytes has a non-redundant role in maintaining a growth plate and sustaining trabecular bone after birth. Loss of Ihh in postnatal chondrocytes results in fusion of the growth plate and a decrease in trabecular bone. In order...

Topics

Join the communities discussing this publication.

Animals, Newborn
Body Size
Chondrocytes
Growth Plate
Hedgehog Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptor, Parathyroid Hormone, Type 1

Source

Open in PubMed Open full text

Identifiers

PMID: 19761883
DOI: 10.1016/j.bone.2009.09.009
PMCID: PMC2818229

Genes

PTH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Partial rescue of postnatal growth plate abnormalities in Ihh mutants by expression of a constitutively active PTH/PTHrP receptor.PMID 19761883Read ↗

Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation.Semantic proximity Read ↗

Targeted expression of constitutively active receptors for parathyroid hormone and parathyroid hormone-related peptide delays endochondral bone formation and rescues mice that lack parathyroid hormone-related peptide.Semantic proximity Read ↗

Indian hedgehog signals independently of PTHrP to promote chondrocyte hypertrophy.Semantic proximity Read ↗

Conditional Deletion of Indian Hedgehog in Limb Mesenchyme Results in Complete Loss of Growth Plate Formation but Allows Mature Osteoblast Differentiation.Semantic proximity Read ↗

Role of parathyroid hormone-related peptide and Indian hedgehog in skeletal development.Semantic proximity Read ↗

Indian hedgehog stimulates periarticular chondrocyte differentiation to regulate growth plate length independently of PTHrP.Semantic proximity Read ↗

Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein.Semantic proximity Read ↗

Ihh and PTH1R signaling in limb mesenchyme is required for proper segmentation and subsequent formation and growth of digit bones.Semantic proximity Read ↗

Gli3 acts as a repressor downstream of Ihh in regulating two distinct steps of chondrocyte differentiation.Semantic proximity Read ↗

Smad4 is required for the normal organization of the cartilage growth plate.Semantic proximity Read ↗

The CREB family of activators is required for endochondral bone development.Semantic proximity Read ↗

Partial rescue of PTH/PTHrP receptor knockout mice by targeted expression of the Jansen transgene.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.